Lot of assumptions here guys. Let's assume Lockers, Greenwood, Flower and Tommy are all fit and Zak is back, also Powell suspended, I would make all these inclusions. With Saints big threat being down our right, I have real problems with Sarges defence, discipline and errors, so reluctantly I would switch Zak to right centre to account for this and leave Morgan at full back.
My last change would be to include Harry Smith on the bench to bring on when Tommy goes off and Shorrocks goes to hooker.
I truly believe that if we can turn up in the pack, we can do them enough damage on our left to make it close.
I would go with Escare, Davies, Zak, Oli, Budgie, George, Shorrocks, Flower, Tommy, Navarette, Greenwood, Isa, Lockers. Subs, Bullock, TT, Paisley, Smith.

Always play your best side available...

Its not about resting players, its about prioritising and being as smart as we can with what we have. If O'Loughlin, Flower etc can only manage one game over the weekend I think its best if that game is Salford.

I doubt Greenwood will be back as it was a bad head knock and its his second one this year.

We’re not in a position where we can simply throw 2 points away. We have to go 100% balls out to win both Easter fixtures with the strongest 17 available. If we play our strongest available 17 against Saints and lose, so be it. We then go with our strongest 17 available against Salford and so on through the season.

^^this

I agree with this. We can't be arrogant enough in the position we're in to think that we will not need the two points available on friday at the end of the season. Even if we do lose as expected on friday the level of defeat could have an impact. Our points difference has been the only thing at times keeping us off bottom in recent weeks and we can't rule out it also being important come season's end. There is also the morale factor, better for the strongest possible squad to go down to a plucky defeat as we did at the HJ a few weeks ago (or even an unexpected win) than for a bunch of fringe players to be given a pasting.

There is also the consequence of doing Ian Watson's team talk for him if we left players out on friday and then brought them back on monday. Nothing would motivate Salford more than a squad aelection that said we're terrified of Saints but we can walk all over you.